Neuroendocrinology: a Clinical Text

Clinical Neuroendocrinology and Neuroendocrine Tumors

Background/Aim: Tumors exhibiting constitutively activated PI(3)K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including neuroendocrine tumors (NETs). However, no preclinical data about the effects of RAD001 on NET cells have been published. In this study, we aime...

Clinical Neuroendocrinology and Neuroendocrine Tumors

Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited. We aimed to identify the role of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) during tumor development and metastasis. Patients an...

Neuroendocrinology Letters

Previous research has revealed that natural and synthetic pheromones can enhance ratings of opposite sex attractiveness. The present study investigated the effects of exposure to male axillary secretions on female ratings of the sexual attractiveness of male stimuli. Thirty-two female undergraduates, half of whom were contraceptive pill users, rated male vignette characters and photographs of m...

Basic and Clinical Neuroscience, Volume 4, Number 3, Full Text

Pioneers in neuroendocrinology

JOSEPH MEITES, BERNARD T. DONOVAN, and SAMUEL M. McCANN (editors), Pioneers in neuroendocrinology, volume II, New York and London, Plenum Press, 1978, 8vo, pp. 422, $39.00. This series of autobiographies continues with twenty-four further essays. The individuals concerned include the three editors, Roger Guillemin, and Solly Zuckerman. These are the second generation of pioneers, whose contribu...